ABSTRACT
Aim: The aim of this study was to develop and validate the situational anxiety scale (SAS) during COVID-19 among adults with type 2 diabetes attending a tertiary diabetes center in Southern India. Materials and Methods: A total of 100 individuals aged from 18 to 65 years with type 2 diabetes attending a tertiary care diabetes center completed a structured SAS at two visits. The first visit (visit 1) survey was conducted in April 2021 and the second visit (visit 2) survey was conducted in March 2022. The SAS was administered to all 100 individuals. The State Trait Anxiety Inventory Scale (STAI-S) consisting of 20 questions was administered to the same 100 individuals in addition to the SAS during Visit 2. Results: The SAS showed good internal consistency for visit 1 (alpha = 0.855) and visit 2 (alpha = 0.795). Exploratory factor analysis showed four factors and explained 69% of variance. The four factors identified were as follows: (1) fear, (2) desire for COVID-free state, (3) lack of interest and energy, and (4) financial worries. A weak positive correlation was observed between SAS visit 2 and STAI-S, and it was statistically significant (r = 0.223;P = 0.026). Conclusion: The SAS is a valid and reliable tool for measuring situational anxiety during pandemics and post-COVID anxiety levels, which can help in the development of a holistic approach.
ABSTRACT
Pharmacovigilance assumes a significant part in the medical care framework through checking and connection of medications and there impacts in the human body. The number of Unfavorable Medication Responses (ADRs) detailed and to comprehend the pharmacovigilance, an elevated degree of mastery is expected to quickly identify drug gambles too as to shield the item against an improper evacuation. The ongoing worldwide organization of pharmacovigilance focuses, composed by the Uppsala Observing Center, would be fortified by a free arrangement of survey. Prescriptions wellbeing checking is a nonstop and dynamic interaction all through every one of the periods of the life pattern of a medication. In the field of medication wellbeing and guideline, various difficulties must be looked in the close future. Above all else, Coronavirus pandemic featured how applicable pharmacovigilance and appropriate risk correspondence during general wellbeing crisis are. Systems including AI methods and the accessibility of enormous measure of electronic medical care information offer an open door for streamlining drug benefit-risk profile assessment in genuine world setting. At last, creative therapeutics, like high level treatment restorative items, computerized therapeutics, antibodies created in light of trend setting innovations, requiring exceptional pharmacovigilance checking have been progressively showcased as of late, frequently upon sped up pathway endorsement. A portion of the difficulties and future open doors in this field are momentaril y talked about beneath. Regulatory authorities, ethics committees, and pharmaceutical and biopharmaceutical businesses are now mandated to be interested in drug safety monitoring. ADRs account for 10% or more of hospitalizations in several nations. Additionally, 10-20% of hospital inpatients are thought to experience ADRs. The only truly effective means of ensuring the public's health is through appropriate and efficient ADR monitoring, or pharmacovigilance. The goal and methodology of pharmacovigilance were outlined in this article along overview of how it is currently practiced in India, its difficulties, and its prospects for the future. The principal objective of pharmacovigilance is subsequently to advance the protected and viable utilization of wellbeing items, specifically by giving ideal data about the security of wellbeing items to patients, medical services experts, and people in general. Pharmacovigilance is hence an action adding to the assurance of patients and keeping up with general wellbeing.Copyright © 2023, Global Research Online. All rights reserved.
ABSTRACT
Lipid nanoparticles (LNPs) have recently emerged as one of the most advanced technologies for the highly efficient in vivo delivery of exogenous mRNA, particularly for COVID-19 vaccine delivery. LNPs comprise four different lipids: ionizable lipids, helper or neutral lipids, cholesterol, and lipids attached to polyethylene glycol (PEG). In this review, we present recent the advances and insights for the design of LNPs, as well as their composition and properties, with a subsequent discussion on the development of COVID-19 vaccines. In particular, as ionizable lipids are the most critical drivers for complexing the mRNA and in vivo delivery, the role of ionizable lipids in mRNA vaccines is discussed in detail. Furthermore, the use of LNPs as effective delivery vehicles for vaccination, genome editing, and protein replacement therapy is explained. Finally, expert opinion on LNPs for mRNA vaccines is discussed, which may address future challenges in developing mRNA vaccines using highly efficient LNPs based on a novel set of ionizable lipids. Developing highly efficient mRNA delivery systems for vaccines with improved safety against some severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants remains difficult.
ABSTRACT
Clinical Surveillance Solutions are the most significant in the concise non-industrial nation people improves requests for caretaking. Coronavirus is as a substitute infectious it is vital to isolation Corona virus people however at the equivalent time clinical analysts need to really take a look at wellness of Corona virus victims additionally. With the helping sort of occurrences it's miles transforming into extreme to safeguard a tune on the wellbeing and prosperity issues of a few isolated people. Underneath the empowered machine plan of a Wi-Fi sensor network in light of IOT development. It is typically utilized for gathering just as moving the special sensors following information in regards to the individuals in medical services communities. This product comprises of Wireless basically based organization (Wi-Fi), having totally outstanding detecting devices connected with the transmitter region the ones are Heart thump detecting unit, Temperature stage detecting unit circulatory strain sensor and heartbeat oximeter. These sensors are straight away associated with the impacted man or lady and amass the client issues by utilizing method of the utilization of detecting gadgets. Similar measurements are conveying remot ely to the beneficiary area this is with the clinical specialist and via that collector inconvenience he'll harvest all refreshes in their clients. Furthermore moreover it will really convey voice word to people to take their prescriptions reasonable time. What's more one sharp ringer will indeed there at patient so as to essentially advocate crisis situation of clients. At the point when patient will squeeze crisis button then the ringer will be ON. © 2022 by the Dankan Gowda V, K. R. Swetha, Namitha A R, Manu Y M, Rashmi G R, Veera Sivakumar Chinamuttevi.
ABSTRACT
Aim: The aim of the study was to evaluate the outlook of general population of India towards dental treatments post-Covid-19 pandemic. Materials and Method: The study sample consisted of 500 participants from various states of India, out of which 480 participants of age ranging from 18 years to above 60 years have taken up the survey. Multiple choice questions were prepared through google forms and circulated via WhatsApp. Results: The majority of the participants preferred to visit a dentist only if required, both before (83.5%) and after (80.5%) the COVID-19 pandemic. 56.9% participants tried to postpone their treatments, in wake of getting infected. 73.1% of participants wanted to wait for few more months till the pandemic subsides. 89.5% of participants desired to have proper social distancing, sanitization and patient personal protection gear in the patient waiting lobby. Conclusion: Dental health care providers have primary goal to serve patients during their times of need. However, the current pandemic makes dentistry a potent channel of community transmission of disease. Hence, current reality requires incorporation of proper guidelines in extending dental services, to the best interest of the patients and dentists as well. Clinical significance: Dental care providers are recognized as high risk health care worker and face the twin challenge of protecting themselves and the patients from community transmission and at the same time ensuring patients continue to have access to urgent/emergency dental care.